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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
23.64
Human Site:
T74
Identified Species:
37.14
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
T74
E
Q
F
T
G
D
H
T
Q
H
F
L
D
G
G
Chimpanzee
Pan troglodytes
XP_524527
588
65774
T74
E
Q
F
T
R
D
H
T
Q
H
F
L
D
G
G
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
T74
E
K
F
I
R
D
H
T
Q
H
F
L
D
G
G
Dog
Lupus familis
XP_537131
637
71340
T124
E
Q
L
T
R
D
H
T
Q
R
F
L
N
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
T74
E
P
L
T
R
G
H
T
Q
H
F
V
N
G
S
Rat
Rattus norvegicus
Q4V8A3
586
65492
T74
E
P
F
T
R
G
H
T
Q
H
F
V
S
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
P64
T
P
V
G
K
P
G
P
P
T
A
P
A
D
R
Chicken
Gallus gallus
Q5ZIU3
526
59419
S63
H
R
R
Q
G
S
S
S
S
L
K
S
T
D
G
Frog
Xenopus laevis
NP_001088793
567
63329
K61
S
G
N
K
L
A
M
K
D
Q
Q
Q
V
K
V
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
Q63
K
P
T
M
K
D
H
Q
A
I
R
G
G
Q
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
S129
D
C
C
E
I
S
E
S
I
Q
A
I
S
L
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
S162
K
Q
S
I
R
D
I
S
P
P
V
I
N
S
S
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
V63
V
K
K
T
N
E
N
V
P
T
G
L
Q
V
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
L17
A
S
S
I
A
M
I
L
E
T
Q
R
N
V
E
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
T155
P
A
Y
T
S
S
N
T
S
L
A
G
N
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
93.3
80
73.3
N.A.
53.3
66.6
N.A.
0
13.3
0
13.3
N.A.
0
N.A.
13.3
13.3
P-Site Similarity:
100
93.3
86.6
80
N.A.
66.6
73.3
N.A.
0
26.6
0
20
N.A.
20
N.A.
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
7
7
0
0
7
0
20
0
7
0
0
% A
% Cys:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
40
0
0
7
0
0
0
20
14
0
% D
% Glu:
40
0
0
7
0
7
7
0
7
0
0
0
0
0
7
% E
% Phe:
0
0
27
0
0
0
0
0
0
0
40
0
0
0
0
% F
% Gly:
0
7
0
7
14
14
7
0
0
0
7
14
7
40
40
% G
% His:
7
0
0
0
0
0
47
0
0
34
0
0
0
0
0
% H
% Ile:
0
0
0
20
7
0
14
0
7
7
0
14
0
0
0
% I
% Lys:
14
14
7
7
14
0
0
7
0
0
7
0
0
7
0
% K
% Leu:
0
0
14
0
7
0
0
7
0
14
0
34
0
7
0
% L
% Met:
0
0
0
7
0
7
7
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
7
0
7
0
14
0
0
0
0
0
34
0
0
% N
% Pro:
7
27
0
0
0
7
0
7
20
7
0
7
0
0
7
% P
% Gln:
0
27
0
7
0
0
0
7
40
14
14
7
7
7
0
% Q
% Arg:
0
7
7
0
40
0
0
0
0
7
7
7
0
0
7
% R
% Ser:
7
7
14
0
7
20
7
20
14
0
0
7
14
14
20
% S
% Thr:
7
0
7
47
0
0
0
47
0
20
0
0
7
0
7
% T
% Val:
7
0
7
0
0
0
0
7
0
0
7
14
7
14
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _